Our Company
We discover and develop plant-derived cell signalling molecules to address challenging medical conditions in humans and companion animals
QBiotics has a 20 year track record in applying a scientifically-based, data-driven approach to discovery of novel, plant-derived small molecule scaffolds for applications in human and animal health using our proprietary discovery platform EcoLogic™.
Our current focus is on two unique clinical assets in oncology and wound healing
We have two high-value, inter-related programmes in oncology and wound healing which we are co-developing for both the human and companion animal markets.
Our lead oncology product, tigilanol tiglate, is a novel small molecule that is administered intratumourally and has potential to treat a broad range of solid tumours, either as a monotherapy or in combination with checkpoint inhibitor drugs (see our oncology programme).In humans, a Phase I/IIa safety study has been completed and we are currently investigating this drug candidate's efficacy in Phase II trials in head and neck cancer, melanoma and soft tissue sarcoma.
In companion animals, tigilanol tiglate has been registered and is marketed (branded as STELFONTA®) as a veterinary pharmaceutical for treatment of canine mast cell tumours in a number of jurisdictions and is under clinical evaluation for additional indications in dogs and horses. Tigilanol tiglate canine.
Our lead wound healing candidate, EBC-1013, is a novel, semi-synthetic small molecule formulated as a topical gel. Preclinical models and veterinary clinical data show its potential to treat a wide range of difficult to manage wounds including chronic non-healing and traumatic acute wounds, as well as burns. This programme is currently in early clinical stage for veterinary applications and in formal preclinical development for humans. Learn more about our wound healing programme.
We have proven ability to successfully partner and to commercialise our products
The potential of our products, and the quality of the underpinning science, is recognised in our commercial partnerships with leading global pharmaceutical companies.
STELFONTA®, the veterinary formulation of our oncology drug tigilanol tiglate, has been approved for treatment of canine mast cell tumours in Europe and is being marketed and distributed under an agreement with Virbac, a global specialist animal health company.
We also have a clinical collaboration with MSD (tradename of Merck & Co. Inc, Kenilworth, NJ, USA) to evaluate the use of tigilanol tiglate as a human pharmaceutical in combination with the their immune checkpoint inhibitor drug Keytruda® (pembrolizumab) in patients with unresectable melanoma.
We have strong intellectual property protection for all our products
All our products are protected by patent families that encompass both composition of matter and use in all major jurisdictions. We also have an ongoing programme of new patent applications and patent extension activities.
A discovery pipeline underpins our potential for long-term growth
Our EcoLogic™ discovery technology provides future opportunities to expand our portfolio of therapeutic indications.
The first of these new areas, a discovery stage, next-generation antibiotic programme is ready to progress to development once our current clinical products are commercialised.
Our Story
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